Yes, kind of.....One of my favorite skin lesions is a relatively common lesion called a keratoacanthoma. These neoplasms (growths, benign or malignant) often arise very quickly and are filled with a central keratin (fibrous proteinaceous material that makes up hairs/nails) material. They are usually very round with pink edges the central area is filled with the hard keratin, which can continue to grow leading to a 'horn'.

The lesions usually arise from a hair follicle and tend to look like ingrown hairs or pimples at the beginning until they take on their characteristic appearance. These lesions tend to resolve on their own over time because they outgrow their blood supply but scar if left to resolve on their own. That being said most patients elect to have them removed surgically in the office because they are tender and we can not reliably predict the histology of the lesion (cancerous or not cancerous).
These lesions are interesting to see in the clinic because they are usually rather alarming to the patients when they're discovered given they are tender, usually somewhat irritated and rather ominous appearing. That being said it's satisfying from my perspective because the treatment is straight-forward and technically enjoyable. You can either shave the lesion off at the based flush with the surrounding skin and then use electrodissection (electrocautery) to destroy remaining cells on the base or do an elliptical surgical excision.
These lesions have been hypothesized to be the entity referred to in more art and literature when characters, such as the devil, have horns.
